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Why is creatinine used to estimate glomerular filtration rate (GFR) in the assessment of kidney function?
Answer:
Creatinine is freely filtered in the glomerulus and is neither secreted nor reabsorbed significantly in the renal tubules.
Explanation:
In order to measure GFR, a substance that will act as an appropriate marker is needed that meets the following criteria:
- Must be freely filtered across the glomerulus into Bowman’s space.
- Must not be reabsorbed or secreted by the nephron.
- Must not be metabolized or produced by the kidney.
- Must not alter GFR.
